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enquirebio 6659-MSM1-P0說明書

　更新時(shí)間：2020-04-28　點(diǎn)擊量：642

enquirebio 6659-MSM1-P0說明書

SOX4 (Master Regulator of Epithelial-Mesenchymal Transition) Ultraspecific Antibody

Tested against >20,000 Human Proteins

$ 199.00 – $ 429.00

 

Product NumberDescriptionPrice
6659-MSM1-P0Size: 20 ug, Tag: Unconjugated$ 199.00
6659-MSM1-P1Size: 100 ug, Tag: Unconjugated$ 429.00
6659-MSM1-P1ABXSize: 100 ug, Tag: Unconjugated$ 429.00


SDS-PAGE Analysis Purified SOX4 Mouse Monoclonal Antibody (SOX4/2540).Confirmation of Integrity and Purity of Antibody.

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SDS-PAGE Analysis Purified SOX4 Mouse Monoclonal Antibody (SOX4/2540).Confirmation of Integrity and Purity of Antibody.

Analysis of Protein Array containing more than 19,000 full-length human proteins using SOX4 Mouse Monoclonal Antibody (SOX4/2540).Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD?s) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD?s) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target. A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.

Formalin-fixed, paraffin-embedded human Breast Carcinoma stained with SOX4 Mouse Monoclonal Antibody (SOX4/2540).

 

人抗SOX4（上皮-間質(zhì)轉(zhuǎn)化的主調(diào)節(jié)劑）抗體產(chǎn)品屬性

物種：人類

經(jīng)過測試的應(yīng)用程序： IHC。

克隆性：單克隆

抗SOX4（上皮-間質(zhì)轉(zhuǎn)化的主調(diào)節(jié)劑）抗體克?。?/strong>SOX4 / 2540

克隆SOX4 / 2540宿主和同種型：小鼠IgG2b，κ

抗人類SOX4（上皮-間質(zhì)轉(zhuǎn)化的主調(diào)節(jié)劑）陽性對照樣品：乳腺癌或結(jié)腸癌

SOX4 / 2540抗體染色的細(xì)胞定位：核

緩沖液和穩(wěn)定劑： 10mM PBS，含0.05％BSA和0.05％疊氮化物。也可不帶BSA和疊氮化物。

抗體濃度： 200 ug / ml

抗體純化方法：從生物反應(yīng)器濃縮物中純化的蛋白A / G。

免疫原：重組全長人SOX4蛋白

儲(chǔ)存條件：儲(chǔ)存于2至8 C（冷藏）。正確存放后可穩(wěn)定保存24個(gè)月。

SOX4（上皮-間質(zhì)轉(zhuǎn)化的主要調(diào)節(jié)劑）以前觀察到的抗體染色模式

限制與保證

inquire Bio的產(chǎn)品SOX4（上皮-間質(zhì)轉(zhuǎn)化的主調(diào)節(jié)劑）MonoSpecific抗體僅可用于研究用途（僅限于RUO）。正確存放后，保證該抗體可工作兩年。

 

SOX4（上皮-間質(zhì)轉(zhuǎn)化的主調(diào)節(jié)劑）一般信息
備用名
SOX; SRY（性別確定區(qū)域Y）框4；含有基因4的SRY盒；SRY相關(guān)的HMG盒基因4；轉(zhuǎn)錄因子SOX-4
分子量
47kDa的
染色體位置
在藍(lán)色冰上的船。
精選數(shù)據(jù)庫和生物信息學(xué)數(shù)據(jù)
基因符號6659
Entrez基因IDSOX4
UniProt IDQ06945
UniGene IDHs643910
COSMIC ID鏈接SOX4
KEGG基因IDhsa：6659
SOX4（上皮-間質(zhì)轉(zhuǎn)化的主調(diào)節(jié)劑）的概述。
SOX4是轉(zhuǎn)錄因子SOX（與SRY相關(guān)的HMG-box）家族的成員，在心臟，胰腺，大腦的器官發(fā)生以及B和T淋巴細(xì)胞分化過程中，在胚胎發(fā)育和細(xì)胞命運(yùn)確定中起關(guān)鍵作用。SOX4基因表達(dá)在許多癌癥類型中均被上調(diào)，并且SOX4活性的增加有助于細(xì)胞轉(zhuǎn)化，細(xì)胞存活和轉(zhuǎn)移?；虮磉_(dá)譜已經(jīng)發(fā)現(xiàn)在正常和癌性乳腺癌上皮細(xì)胞中TGF-β誘導(dǎo)的上皮-間質(zhì)轉(zhuǎn)化（EMT）期間具有上調(diào)活性的SOX4。SOX4對于體外EMT和細(xì)胞存活以及體內(nèi)原發(fā)性腫瘤生長和轉(zhuǎn)移是*的。通過控制表觀遺傳修飾因子Ezh2的表達(dá)，SOX4被確定為EMT的主要調(diào)控因子。